Pancreatic Islet Cell Transplantation
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Reasons for Procedure
- Toxicity from immunosuppressive agents
- Injury to the liver or the pancreas
- Cholesterol problems
- Sensitization—The recipient may form antibodies to future islet cells for repeat transplant.
- Nausea, vomiting, and abdominal pain
- Blood clots
- Worsening of kidney function
- Worsening of high blood pressure
- Kidney disease
- Bleeding disorders
What to Expect
Prior to Procedure
Description of Procedure
Immediately After Procedure
How Long Will It Take?
How Much Will It Hurt?
Average Hospital Stay
- Keep the incision wound clean.
- Follow your doctor’s instructions about wound care.
- Check your blood glucose frequently. Follow your doctor’s instructions.
- Closely control blood sugar levels with insulin.
Call Your Doctor
- Signs of infection, including fever and chills
- Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site
- Cough, shortness of breath, chest pain, or severe nausea or vomiting
- High or low blood glucose levels
American College of Surgeons http://www.facs.org/
American Diabetes Association http://www.diabetes.org/
Canadian Diabetes Association http://www.diabetes.ca/
Canadian Digestive Health Foundation http://www.cdhf.ca/aboutcdhf.htm/
Bertuzzi F, Marzorati S, Secchi A. Islet cell transplantation. Curr Mol Med . 2006;6:369-74.
Campbell, PM, Senior, PA, Salam, A, et al. High risk of sensitization after failed islet transplantation. Am J Transplant. 2007; 7:2311.
Demartines N, Schiesser M, Clavien PA. An evidence-based analysis of simultaneous pancreas-kidney and pancreas transplantation alone. Am J Transplant . 2005;5:2688-97.
Fiorina P, Secchi A. Pancreatic islet cell transplant for treatment of diabetes. Endocrinol Metab Clin N Am . 2007;36:999-1013.
Hogan A, Pileggi a, Ricordi C. Transplantation: current developments and future directions: the future of clinical islet transplantation as a cure for diabetes. Front Biosci . 2008;13: 1192-205.
Leitao CB, Cure P, Theravanij T, et al. Current challenges in islet transplantation. Curr Diab Rep . 2008;8:324-31.
Roberson RP. Islet transplantation as a treatment for diabetes: a work in progress. N Engl J Med . 2004;350:694-705.
Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med . 2006; 355:1318.
Townsend CM, Beauchamp RD, Evers BM, et al., eds. Transplantation of abdominal organs. Sabiston Textbook of Surgery . 17th ed. Philadelphia, PA: Elsevier; 2004.
6/3/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Mills E, Eyawo O, Lockhart I, Kelly S, Wu P, Ebbert JO. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.e8.
- Reviewer: Kim Carmichael, MD
- Review Date: 11/2012 -
- Update Date: 11/26/2012 -