(Granulocytopenia; Granulopenia; Neutropenia)
- Acquired—develops after medical treatment or specific drugs. May appear suddenly or develop over time.
Congenital—present at birth
- Cyclic neutropenia—cyles up and down over 21 day period
- Severe congenital neutropenia
|White Blood Cells|
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- Infections—caused by virus, bacteria or parasite
- Underlying inflammatory condition
- Drugs—used in medical treatment or recreational use
- Autoimmune disease—your immune systems attacks your own tissue such as white blood cells
- Illnesses or damage to bone marrow
- Certain toxins
- Poor nutrition—particularly low protein intake
- Undergoing chemotherapy treatment for cancer
- Taking certain medications—including some antithyroid medication, antidepressants, antihistamines, anticonvulsants
- Exposure to certain chemical toxins or radiation
- Autoimmune diseases
- Enlargement of the spleen
- Vitamin B-12 or folate deficiency
- Leukemia or myelodysplastic syndromes
- Aplastic anemia or other diseases of the bone marrow
- Family history of certain genetic diseases
- Rapid onset of fever, chills, jaundice , weakness, or sore throat
- Ulcers in the mouth
- Bleeding gums
- Infections, including certain fungal infection (these types of infections are often only present in people with compromised immune systems)
- Severe recurrent bacterial infections
- Mild infections of skin, mouth, and nose
- Failure to thrive—with persitent agranulocytosis
- White blood cell count
- Antineutrophil antibodies—for people with autoimmune disease
- Genetic tests may be needed in some people
- Bone marrow test
- Urine or other fluid tests—to look for infectious agents
Medication for Infections Treatment
- Treat infection that could be causing agranulocytosis.
- Treat an infection that resulted from agranulocytosis.
- Prevent an infection in people at high risk. This may include people with cancer or immune disorders.
White Blood Cell-stimulating Factors
Remove Causative Agent
American Dental Association http://www.ada.org/
National Organization for Rare Disorders, Inc. http://www.rarediseases.org/
Canadian Family Physician http://www.cfpc.ca/
Health Canada http://www.hc-sc.gc.ca/index-eng.php/
Boulton F, Cooper C, Hagenbeek A, et al. Neutropenia and agranulocytosis in England and Wales: incidence and risk factors. American Journal of Hepatology . 2003 Apr;72(4):248-54. PubMed website. Available at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list%5Fuids=12666135 . Accessed December 18, 2006.
Hoffman R. et al. Hematology: Basic Principles and Practice . 4th ed. Philadelphia: Elsevier, 2005.
Mandell GL et al. Principles and Practice of Infectious Diseases . 6th ed. London: Churchill Livingstone, 2005.
Neutropenia. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us . Updated September 27, 2012. Accessed December 27, 2012.
- Reviewer: Michael Woods, MD
- Review Date: 11/2012 -
- Update Date: 11/26/2012 -